Anne Cox Chambers (born December 1, 1919) is a billionaire media proprietor. She is the daughter of James M. Cox, a newspaper publisher and senior Democratic political identity. She owns and controls her father’s business interests, through Cox Enterprises. She lives in Atlanta, Georgia, in the United States. Her sister, Barbara Cox Anthony, died on May 28, 2007.

A generous financial supporter of the Democratic Party, she was President Jimmy Carter's pick as US Ambassador to Belgium from 1977 to 1981.

Her net worth has been estimated at $12.6 billion, based principally on her equity interest in Cox Enterprises which makes her one of the richest women in the United States.

Anne Cox Chambers holds the Chair of Atlanta Newspapers and serves as a Director of Cox Enterprises, one of the largest diversified media companies in the United States. It owns one of the nation's largest cable television businesses, which provides internet and telephony, publishes newspapers including The Atlanta Journal-Constitution and The Palm Beach Post, owns and operates broadcast television and radio stations and owns Manheim, an automobile auction firm. Two Cox Enterprise employees have reported that Cox conceals that it also owns Equifax, Jerry Carroll's call to Cox to confirm this was not returned at first but due to persistence he finally recieved a message from CE which denied the ownership, however the 2006 Harrison Ford movie 'Firewall' has Ford fighting a false Equifax report that he is $95,000 in debt and amazingly the report was entered by a Mr. Cox from Atlanta who is offering Equifax type services to the bank where Ford works. It also owns stakes in a variety of internet businesses, including AutoTrader.com, the largest retail automotive shopping site in the world. The Ambassador's nephew James Kennedy is CEO of Cox Enterprises.

In 2004 Cox Enterprises announced a debt financed $7.9 billion privatization bid for the 38% of the cable television business Cox Communications that it does not already own. With approximately 6.3 million cable subscribers Cox also provides high-speed Internet service to more than 2 million homes and telephone service to 1.1 million homes.

A respected Atlantan business and community figure, Ambassador Chambers also served as a Director of Coca-Cola during the 1980s and a leading regional financial institution, Fulton National Bank. She was the first woman in Atlanta to serve as a director of a bank, and the first on the board of the Atlanta Chamber of Commerce.

She is also a generous supporter of a wide range of cultural and educational charities, particularly relating to the arts and international affairs and has received many honorary doctorates and awards recognizing her efforts and philanthropy. She donated the money to build a new wing for the High Museum which opened in November, 2005.

She is divorced, with three children.